Alcoholic liver disease-from steatosis to cirrhosis - a biochemistry approach

Nowadays, chronic alcoholism and its health implications represent a global concern. Over three million deaths are linked to chronic alcohol intake every year. This article aims to spread awareness about the negative impact ethanol can have on almost every organ in the body, especially the liver. Un...

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Bibliographic Details
Published in:Journal of medicine and life 2021-09, Vol.14 (5), p.594-599
Main Authors: Cioarca-Nedelcu, Ruxandra, Atanasiu, Valeriu, Stoian, Irina
Format: Article
Language:English
Subjects:
Alcoholism
Cirrhosis
Ethanol
Fatty liver
Fatty Liver - metabolism
Fatty Liver - pathology
Humans
Kinases
Lipids
Liver - pathology
Liver cirrhosis
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases, Alcoholic - metabolism
Liver Diseases, Alcoholic - pathology
Oxidation
Oxidative Stress
Review
Steatosis
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Summary:Nowadays, chronic alcoholism and its health implications represent a global concern. Over three million deaths are linked to chronic alcohol intake every year. This article aims to spread awareness about the negative impact ethanol can have on almost every organ in the body, especially the liver. Understanding ethanol metabolism and the cellular pathways through which alcohol increases liver oxidative stress may prevent a broad spectrum of hepatic lesions such as steatosis, steatohepatitis, and, ultimately, cirrhosis. After a short review of ethanol metabolism and liver oxidative stress, each hepatic lesion will be individually discussed regarding the mechanism of apparition, treatment, and future targeted therapies.
ISSN:1844-122X
1844-3117
DOI:10.25122/jml-2021-0081