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Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry

Abstract Background Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2022-01, Vol.24 (1), p.141-152
Main Authors: Erker, Craig, Lane, Adam, Chaney, Brooklyn, Leary, Sarah, Minturn, Jane E, Bartels, Ute, Packer, Roger J, Dorris, Kathleen, Gottardo, Nicholas G, Warren, Katherine E, Broniscer, Alberto, Kieran, Mark W, Zhu, Xiaoting, White, Peter, Dexheimer, Phillip J, Black, Katie, Asher, Anthony, DeWire, Mariko, Hansford, Jordan R, Gururangan, Sridharan, Nazarian, Javad, Ziegler, David S, Sandler, Eric, Bartlett, Allison, Goldman, Stewart, Shih, Chie-Schin, Hassall, Tim, Dholaria, Hetal, Bandopadhayay, Pratiti, Samson, Yvan, Monje, Michelle, Fisher, Paul G, Dodgshun, Andrew, Parkin, Sarah, Chintagumpala, Murali, Tsui, Karen, Gass, David, Larouche, Valerie, Broxson, Emmett, Garcia Lombardi, Mercedes, Wang, Stacie Shiqi, Ma, Jie, Hawkins, Cynthia, Hamideh, Dima, Wagner, Lars, Koschmann, Carl, Fuller, Christine, Drissi, Rachid, Jones, Blaise V, Leach, James, Fouladi, Maryam
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Language:English
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Summary:Abstract Background Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR). Methods Patients ≥10 years of age at diagnosis enrolled in the IDIPGR with imaging confirmed DIPG diagnosis were included. The primary outcome was overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term survivors (STS) (
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noab140