Mass spectrometry applied to diagnosis, prognosis, and therapeutic targets identification for the novel coronavirus SARS-CoV-2: A review

Mass spectrometry (MS) has found numerous applications in medicine and has been widely used in the detection and characterization of biomolecules associated with viral infections such as COVID-19. COVID-19 is a multisystem disease and, therefore, the need arises to carry out a careful and conclusive...

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Bibliographic Details
Published in:Analytica chimica acta 2022-02, Vol.1195, p.339385-339385, Article 339385
Main Authors: Lima, Nerilson M., Fernandes, Bruno L.M., Alves, Guilherme F., de Souza, Jéssica C.Q., Siqueira, Marcelo M., Patrícia do Nascimento, Maria, Moreira, Olívia B.O., Sussulini, Alessandra, de Oliveira, Marcone A.L.
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 Testing
Diagnosis
Humans
Laboratories, Clinical
Mass Spectrometry
Prognosis
Review
SARS-CoV-2
Therapeutic targets
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Summary:Mass spectrometry (MS) has found numerous applications in medicine and has been widely used in the detection and characterization of biomolecules associated with viral infections such as COVID-19. COVID-19 is a multisystem disease and, therefore, the need arises to carry out a careful and conclusive assessment of the pathophysiological parameters involved in the infection, to develop an effective therapeutic approach, assess the prognosis of the disease, and especially the early diagnosis of the infected population. Thus, the urgent need for highly accurate methods of diagnosis and prognosis of this infection presents new challenges for the development of laboratory medicine, whose methods require sensitivity, speed, and accuracy of the techniques for analyzing the biological markers involved in the infection. In this context, MS stands out as a robust analytical tool, with high sensitivity and selectivity, accuracy, low turnaround time, and versatility for the analysis of biological samples. However, it has not yet been adopted as a frontline clinical laboratory technique. Therefore, this review explores the potential and trends of current MS methods and their contribution to the development of new strategies to COVID-19 diagnosis and prognosis and how this tool can assist in the discovery of new therapeutic targets, in addition, to comment what could be the future of MS in medicine. [Display omitted] •Trending strategies on MS analysis of biological samples infected with SARS-CoV-2.•Omic approaches applied to COVID-19 diagnosis, prognosis, and therapeutic targets.•Compilation of SARS-CoV-2 infection insights through MS-acquired data.•MS feasibility to generate valuable molecular information for medical purposes.
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2021.339385