Nanomedicines in B cell-targeting therapies

B cells play multiple roles in immune responses related to autoimmune diseases as well as different types of cancers. As such, strategies focused on B cell targeting attracted wide interest and developed intensively. There are several common mechanisms various B cell targeting therapies have relied...

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Bibliographic Details
Published in:Acta biomaterialia 2022-01, Vol.137, p.1-19
Main Authors: Wang, Jiawei, Yang, Jiyuan, Kopeček, Jindřich
Format: Article
Language:English
Subjects:
Antigens
Autoimmune diseases
Autoimmunity
B cell targeting
B-cell receptor
Blood circulation
Cell survival
Depletion
Drug carriers
Drug delivery
Drug Delivery Systems
Humans
Immune checkpoint
Immunosuppressive agents
Immunotherapy
Low molecular weights
Lymphocytes
Lymphocytes B
Lymphocytes T
Molecular weight
Nanomedicine
Nanomedicines
Nanotechnology
Neoplasms - drug therapy
Toxicity
Weight reduction
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Summary:B cells play multiple roles in immune responses related to autoimmune diseases as well as different types of cancers. As such, strategies focused on B cell targeting attracted wide interest and developed intensively. There are several common mechanisms various B cell targeting therapies have relied on, including direct B cell depletion, modulation of B cell antigen receptor (BCR) signaling, targeting B cell survival factors, targeting the B cell and T cell costimulation, and immune checkpoint blockade. Nanocarriers, used as drug delivery vehicles, possess numerous advantages to low molecular weight drugs, reducing drug toxicity, enhancing blood circulation time, as well as augmenting targeting efficacy and improving therapeutic effect. Herein, we review the commonly used targets involved in B cell targeting approaches and the utilization of various nanocarriers as B cell-targeted delivery vehicles. As B cells are engaged significantly in the development of many kinds of diseases, utilization of nanomedicines in B cell depletion therapies have been rapidly developed. Although numerous studies focused on B cell targeting have already been done, there are still various potential receptors awaiting further investigation. This review summarizes the most relevant studies that utilized nanotechnologies associated with different B cell depletion approaches, providing a useful tool for selection of receptors, agents and/or nanocarriers matching specific diseases. Along with uncovering new targets in the function map of B cells, there will be a growing number of candidates that can benefit from nanoscale drug delivery. [Display omitted]
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2021.10.024