Melanotic neuroectodermal tumor of infancy in the mandible: A case report

Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted trea...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-12, Vol.100 (50), p.e28001-e28001
Main Authors: Takeuchi, Ryoko, Funayama, Akinori, Oda, Yohei, Abé, Tatsuya, Yamazaki, Manabu, Maruyama, Satoshi, Hayashi, Takafumi, Tanuma, Jun-Ichi, Kobayashi, Tadaharu
Format: Article
Language:English
Subjects:
Biopsy
Child
Clinical Case Report
Humans
Infant
Male
Mandible - diagnostic imaging
Mandible - surgery
Mandibular Neoplasms - diagnosis
Mandibular Neoplasms - pathology
Mandibular Neoplasms - surgery
Mandibular Osteotomy
Neuroectodermal Tumor, Melanotic - diagnosis
Neuroectodermal Tumor, Melanotic - pathology
Neuroectodermal Tumor, Melanotic - surgery
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Melanocytic neuroectodermal tumor of infancy (MNTI) is a rare benign pigmented neoplasm that arises from the neural crest and has an aggressive growth pattern. It is predominantly seen in infants under 1 year of age, and the most common site of involvement is the maxilla. The currently accepted treatment is removal by surgical resection. Herein, we report a case of MNTI that involved the anterior alveolar ridge of the mandible in a 6-month-old infant. A case of a 6-month-old male child with a huge mass in the anterior alveolar ridge of the mandible. The tumor was diagnosed using histopathological and immunohistochemical techniques on the biopsy specimen obtained following incisional biopsy. Based on the findings, a final diagnosis of MNTI was established. Radical resection of the tumor was performed, after determining the extent of resection by referring to the mandibular 3D model created using the pre-operative CT data. The postoperative course was uneventful, and no recurrence has been observed to date for more than 4 years after surgery. This case emphasizes that early diagnosis and radical surgery are critical to the effective treatment, as MNTI exhibits rapid and destructive growth. It also requires careful and close follow-up because of high recurrence rates.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000028001