Quantification of torque teno virus (TTV) DNA in saliva and plasma samples in patients at short time before and after kidney transplantation

Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been su...

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Bibliographic Details
Published in:Journal of oral microbiology 2022-01, Vol.14 (1), p.2008140
Main Authors: Batista, Alexandre Mendes, Caetano, Matheus W., Stincarelli, Maria A., Mamana, Ana C., Zerbinati, Rodrigo Melim, Sarmento, Dmitry J. S., Gallottini, Marina, Caixeta, Rafael A. V., Medina-Pestana, José, Hasséus, Bengt, Zanella, Louise, Tozetto-Mendoza, Tania R., Giannecchini, Simone, Braz-Silva, Paulo H.
Format: Article
Language:English
Subjects:
dynamics
human virome
immunosuppression
load
maintenance
Microbiology
Microbiology in the medical area
Mikrobiologi inom det medicinska området
Original
rejection
replication
Saliva
solid organ transplantation
stem-cell transplantation
torque teno
torque teno virus
torquetenovirus
viremia
virus
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Summary:Several reports have proposed that the viral load of torque teno virus (TTV) in plasma is a biomarker of immune function in solid organ transplantation (SOT) and in allogeneic hematopoietic stem cell transplantation. Additionally, for the latter one, TTV-DNA quantification in saliva has also been suggested. to investigate the correlation between the TTV viral load and immune function in paired saliva and plasma samples in patients on kidney transplantation. TTV-DNA viral load was quantified in paired samples of saliva and plasma from 71 patients before and a short-time after renal-transplantation by real-time PCR. The data obtained from 213 paired samples showed a slight consistency in the comparison between saliva and plasma, with prevalence of TTV-DNA being 58%, 52% and 60% in saliva samples and 60%, 73% and 90% in plasma samples before and at 15-20 and 45-60 days after transplantation, respectively. Additionally, a high TTV viral load was observed in plasma at 15-20 and 45-60 days after transplantation compared to that observed in saliva at the same time. Overall, monitoring TTV-DNA in saliva samples could be an additional fast non-invasive option to assess the immune functionality in SOT populations.
ISSN:2000-2297
2000-2297
DOI:10.1080/20002297.2021.2008140