Intestinal IL-17R signaling controls SIgA and oxidase balance in C. rodentium infection

Type 17 cytokines have been strongly implicated in mucosal immunity in part by regulating the production of antimicrobial peptides. Using a mouse model of C. rodentium infection which causes colitis, we found that intestinal IL-17RA and IL-17RC was partially required for control of infection in the...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2021-01, Vol.206 (4), p.766-775
Main Authors: Matsunga, Yasuka, Clark, Trevon, Wanek, Alanna G., Bitoun, Jacob P., Gong, Qingqing, Good, Misty, Kolls, Jay K.
Format: Article
Language:English
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Summary:Type 17 cytokines have been strongly implicated in mucosal immunity in part by regulating the production of antimicrobial peptides. Using a mouse model of C. rodentium infection which causes colitis, we found that intestinal IL-17RA and IL-17RC was partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Tnsf13 . Reduced Tnfsf13 expression was associated with a profound defect in generating C. rodentium specific IgA+ antibody secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen specific IgA+ antibody secreting cells.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2000591