NEAT1 and MALAT1 are highly expressed in saliva and nasopharyngeal swab samples of COVID‐19 patients

COVID‐19, caused by the SARS‐CoV‐2 virus, has become a significant global public health problem, with a wide variety of clinical manifestations and disease progression outcomes. LncRNAs are key regulators of the immune response and have been associated with COVID‐19 risk infection. Previous studies...

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Bibliographic Details
Published in:Molecular oral microbiology 2021-12, Vol.36 (6), p.291-294
Main Authors: Rodrigues, Ana Carolina, Adamoski, Douglas, Genelhould, Gustavo, Zhen, Felipe, Yamaguto, Guilherme Eiji, Araujo‐Souza, Patrícia Savio, Nogueira, Meri Bordignon, Raboni, Sonia Mara, Bonatto, Ana Claudia, Gradia, Daniela Fiori, Carvalho de Oliveira, Jaqueline
Format: Article
Language:English
Subjects:
Biomarkers
Blood cells
COVID-19
Health risks
Humans
Immune response
Infections
Infectivity
lncRNA
MALAT1
nasopharyngeal samples
Nasopharynx - chemistry
NEAT1
Non-coding RNA
Original
Patients
Peripheral blood
Public health
RNA, Long Noncoding - analysis
RNA, Long Noncoding - genetics
Saliva
Saliva - chemistry
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
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Summary:COVID‐19, caused by the SARS‐CoV‐2 virus, has become a significant global public health problem, with a wide variety of clinical manifestations and disease progression outcomes. LncRNAs are key regulators of the immune response and have been associated with COVID‐19 risk infection. Previous studies focused mainly on in‐silico analysis of lncRNA expression in the lungs or peripheral blood cells. We evaluated the expression of lncRNAs NEAT1, MALAT1, and MIR3142 in saliva and nasopharyngeal swab from SARS‐CoV‐2 positive (n = 34) and negative patients (n = 46). A higher expression of the lncRNAs NEAT1 and MALAT1 (p 
ISSN:2041-1006
2041-1014
2041-1014
DOI:10.1111/omi.12351