Circular RNA‐associated ceRNA network involved in HIF‐1 signalling in triple‐negative breast cancer: circ_0047303 as a potential key regulator

The aggressive and highly metastatic nature of triple‐negative breast cancer (TNBC) causes patients to suffer from the poor outcome. HIF‐1 signalling pathway is a prominent pathway that contributes to angiogenesis and metastasis progression in tumours. On the contrary, the undeniable importance of c...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2021-12, Vol.25 (24), p.11322-11332
Main Authors: Darbeheshti, Farzaneh, Mahdiannasser, Mojdeh, Noroozi, Zahra, Firoozi, Zahra, Mansoori, Behnam, Daraei, Abdolreza, Bastami, Milad, Nariman‐Saleh‐Fam, Ziba, Valipour, Elahe, Mansoori, Yaser
Format: Article
Language:English
Subjects:
Angiogenesis
Bioinformatics
Breast cancer
Case-Control Studies
Cell Line
ceRNA network
Chemotherapy
circ_0047303
Circular RNA
Computational Biology - methods
Datasets
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
HIF‐1 signalling
Humans
Hypoxia
Hypoxia-Inducible Factor 1 - metabolism
Investigations
Medical prognosis
Metastases
Metastasis
microarray
MicroRNAs
MicroRNAs - genetics
Neoplasm Grading
Neoplasm Staging
Non-coding RNA
Original
Prognosis
Proteins
RNA, Circular
RNA, Messenger - genetics
RNA, Untranslated - genetics
ROC Curve
Signal Transduction
Software
Therapeutic targets
Triple Negative Breast Neoplasms - diagnosis
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - metabolism
Triple Negative Breast Neoplasms - mortality
triple‐negative breast cancer
Tumors
Variance analysis
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Summary:The aggressive and highly metastatic nature of triple‐negative breast cancer (TNBC) causes patients to suffer from the poor outcome. HIF‐1 signalling pathway is a prominent pathway that contributes to angiogenesis and metastasis progression in tumours. On the contrary, the undeniable importance of circular RNAs (circRNAs) as multifunctional non‐coding RNAs (ncRNAs) has been identified in breast cancer. These ncRNAs owing to their high stability and specificity have been becoming a hotspot in cancer researches. circRNAs act as competing endogenous RNAs (ceRNAs) and compete with mRNAs for shared miRNAs, thus modulate gene expression. Since the most dysregulated biological functions in TNBC are associated with cellular invasion, understanding the molecular pathogenesis of these processes is a crucial step towards the development of new treatment approaches. The purpose of this study is to undermine the circRNA‐associated ceRNA network involved in HIF‐1 signalling in TNBC using an integrative bioinformatics approach. In the next step, the novel circ_0047303‐mediated ceRNA regulatory axes have been extracted and validated across TNBC samples. We show that circ_0047303 has the highest degree in the circRNA‐associated ceRNA network and shows a significant up‐expression in TNBC. Moreover, our results suggest that circ_0047303 could mediate the upregulation of key angiogenesis‐related genes, including HIF‐1, EIF4E2 and VEGFA in TNBC through sponging the tumour‐suppressive miRNAs. The circ_0047303 could be a promising molecular biomarker and/or therapeutic target for TNBC.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.17066