Predictive Value of an Age-Based Modification of the National Early Warning System in Hospitalized Patients With COVID-19

Abstract Background Early recognition of high-risk patients with coronavirus disease 2019 (COVID-19) may improve outcomes. Although many predictive scoring systems exist, their complexity may limit utility in COVID-19. We assessed the prognostic performance of the National Early Warning Score (NEWS)...

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Bibliographic Details
Published in:Open forum infectious diseases 2021-12, Vol.8 (12), p.ofab421-ofab421
Main Authors: Maves, Ryan C, Richard, Stephanie A, Lindholm, David A, Epsi, Nusrat, Larson, Derek T, Conlon, Christian, Everson, Kyle, Lis, Steffen, Blair, Paul W, Chi, Sharon, Ganesan, Anuradha, Pollett, Simon, Burgess, Timothy H, Agan, Brian K, Colombo, Rhonda E, Colombo, Christopher J
Format: Article
Language:English
Subjects:
Coronaviruses
Hospital patients
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Summary:Abstract Background Early recognition of high-risk patients with coronavirus disease 2019 (COVID-19) may improve outcomes. Although many predictive scoring systems exist, their complexity may limit utility in COVID-19. We assessed the prognostic performance of the National Early Warning Score (NEWS) and an age-based modification (NEWS+age) among hospitalized COVID-19 patients enrolled in a prospective, multicenter US Military Health System (MHS) observational cohort study. Methods Hospitalized adults with confirmed COVID-19 not requiring invasive mechanical ventilation at admission and with a baseline NEWS were included. We analyzed each scoring system’s ability to predict key clinical outcomes, including progression to invasive ventilation or death, stratified by baseline severity (low [0–3], medium [4–6], and high [≥7]). Results Among 184 included participants, those with low baseline NEWS had significantly shorter hospitalizations (P 
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab421