Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review

Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic fea...

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Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2021-12, Vol.15 (4), p.1265-1283
Main Authors: de Souza Vieira, Gustavo, de Pinho Montovani, Pâmella, Rozza-de-Menezes, Rafaela Elvira, Cunha, Karin Soares Gonçalves, Conde, Danielle Castex
Format: Article
Language:English
Subjects:
Age Factors
beta Catenin - genetics
Dentistry
DNA Copy Number Variations
Humans
Jaw Neoplasms - genetics
Jaw Neoplasms - pathology
Keratins - metabolism
Ki-67 Antigen - metabolism
Medicine
Medicine & Public Health
Mutation
Neoplasm Recurrence, Local
Odontogenic Tumors - genetics
Odontogenic Tumors - pathology
Oral and Maxillofacial Surgery
Otorhinolaryngology
Pathology
Review
Sex Factors
Tumor Suppressor Protein p53 - metabolism
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Summary:Dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC) form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. The aim of this study was to perform a comparative systematic review of the clinicopathological, genetic, therapeutic, and prognostic features of DGCT and GCOC. The electronic search was performed until December 2020 on seven electronic databases. Case reports, series, and research studies with enough histopathological criteria for diagnosis and all genomic studies were included. Both DGCT and GCOC showed a male prevalence (p = 0.043), with mandibular and maxillary predilections, respectively (p = 0.008). Peripheral DGCT (DGCTp) affected most elderly people (p 
ISSN:1936-0568
1936-055X
1936-0568
DOI:10.1007/s12105-021-01347-z