The Risk of Fasting Triglycerides and its Related Indices for Ischemic Cardiovascular Diseases in Japanese Community Dwellers: the Suita Study

Aim: A prospective cohort study in a Japanese urban general population was performed to investigate whether triglyceride (TG) and its related indices were associated with the risk for the incidence of ischemic cardiovascular disease (CVD) after the adjustment for low-density lipoprotein cholesterol...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2021/12/01, Vol.28(12), pp.1275-1288
Main Authors: Higashiyama, Aya, Wakabayashi, Ichiro, Okamura, Tomonori, Kokubo, Yoshihiro, Watanabe, Makoto, Takegami, Misa, Honda-Kohmo, Kyoko, Okayama, Akira, Miyamoto, Yoshihiro
Format: Article
Language:eng ; jpn
Subjects:
Cardiometabolic index
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
Fasting - blood
Female
Hazard ratio
Humans
Incidence
Independent Living - statistics & numerical data
Japan - epidemiology
LDL-C
Male
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - diagnosis
Myocardial Ischemia - epidemiology
Original
Predictive Value of Tests
Prognosis
Prospective cohort study
Prospective Studies
TG/HDL-C ratio
Triglycerides - blood
Urban Population
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim: A prospective cohort study in a Japanese urban general population was performed to investigate whether triglyceride (TG) and its related indices were associated with the risk for the incidence of ischemic cardiovascular disease (CVD) after the adjustment for low-density lipoprotein cholesterol (LDL-C) in Asian community dwellers. Methods: A 15.1-year prospective cohort study was performed in 6,684 Japanese community dwellers aged 30–79 years without a history of CVD and whose fasting TG levels were ＜400 mg/dL. After adjusting for covariates, including LDL-C, the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of the deciles (D) of TG and those of 1-standard deviation (SD) increment of log-transformed TG (1-SD of TG) according to LDL-C level (≥ 140 and ＜140 mg/dL) for ischemic CVD incidence were estimated. The multivariable-adjusted HRs and 95%CIs of the quintiles (Q) of TG, TG/HDL-C, and the cardiometabolic index (CMI) for ischemic CVD were also estimated. Results: In 101,230 person-years, 464 ischemic CVD cases occurred. For D10 of TG, the HR (95%CI) was 1.56 (1.05–2.32), and for 1-SD of TG, it was 1.30 (1.00–1.70) in participants with LDL-C ＜140 mg/dL and 1.07 (0.77–1.50) in those with LDL-C ≥ 140 mg/dL. For Q 5 of the CMI, the multivariable-adjusted HR was higher than those of TG and TG/HDL-C. Conclusions: Fasting TG was an independent predictor for ischemic CVD incidence after adjusting for LDL-C in Japanese community dwellers with TG ＜400 mg/dL. Among TG, TG/HDL-C, and the CMI, the CMI could be the most powerful predictor for ischemic CVD.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.62730