An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

Significance Low-cost and rapidly distributable vaccines are urgently needed to combat COVID-19 and future pandemics, especially for developing countries and other low-resource settings. DNA vaccines are inexpensive, rapidly developed, and safe, but require bulky and expensive electroporation device...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2021-11, Vol.118 (45), p.1
Main Authors: Xia, Dengning, Jin, Rui, Byagathvalli, Gaurav, Yu, Huan, Ye, Ling, Lu, Chao-Yi, Bhamla, M. Saad, Yang, Chinglai, Prausnitz, Mark R.
Format: Article
Language:English
Subjects:
Accessibility
Antibodies
Arrays
Biological Sciences
Coronaviruses
COVID-19
Deoxyribonucleic acid
DNA
DNA vaccines
Electric field strength
Electric pulses
Electrodes
Electroporation
Epidemics
Epidermis
Immune response
Immunization
Low cost
Needles
Pandemics
Physical Sciences
Piezoelectricity
Power sources
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral diseases
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Summary:Significance Low-cost and rapidly distributable vaccines are urgently needed to combat COVID-19 and future pandemics, especially for developing countries and other low-resource settings. DNA vaccines are inexpensive, rapidly developed, and safe, but require bulky and expensive electroporation devices for effective vaccination, which presents challenges to affordable and mass vaccination. We developed an ultra-low-cost (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2110817118