The Landmark Series: Management of Small Bowel Neuroendocrine Tumors

Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen surviva...

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Bibliographic Details
Published in:Annals of surgical oncology 2021-05, Vol.28 (5), p.2741-2751
Main Authors: Tran, Catherine G., Sherman, Scott K., Howe, James R.
Format: Article
Language:English
Subjects:
Endocrine Tumors
Humans
Intestinal Neoplasms - therapy
Intestine, Small
Medical treatment
Medicine
Medicine & Public Health
Neuroendocrine tumors
Neuroendocrine Tumors - therapy
Oncology
Pancreatic Neoplasms
Radiation therapy
Retrospective Studies
Small intestine
Somatostatin
Surgery
Surgical Oncology
Survival
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Summary:Surgical resection is the foundation for treatment of small bowel neuroendocrine tumors (SBNETs). Guidelines for surgical management of SBNETs rely on retrospective data, which suggest that primary tumor resection and cytoreduction improve symptoms, prevent future complications, and lengthen survival. In advanced NETs, improvement in progression-free survival has been reported in large, randomized, controlled trials of various medical treatments, including somatostatin analogues, targeted therapy, and peptide receptor radionuclide therapy. This review discusses important studies influencing the management of SBNETs and the limitations of current evidence regarding surgical interventions for SBNETs.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09566-4