Central Autonomic Regulation Assessed by Pupillary Light Reflex is Impaired in Children With Attention Deficit Hyperactivity Disorder

It is assumed that the Attention Deficit Hyperactivity Disorder is associated with the central autonomic dysregulation, however, the studies are rare. Analysis of pupillary light reflex represents a non-invasive tool to provide information related to the central autonomic regulation; thus, we aimed...

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Bibliographic Details
Published in:Physiological research 2020-12, Vol.69 (Suppl 3), p.S513-S521
Main Authors: HAMRAKOVA, A, ONDREJKA, I, SEKANINOVA, N, BONA OLEXOVA, L, VISNOVCOVA, Z, CESNEKOVA, D, HRTANEK, I, OPPA, M, HUTKA, P, TONHAJZEROVA, Ingrid
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Autonomic nervous system
Child & adolescent psychiatry
Children
Ethics
Hyperactivity
Light
Mental disorders
Nervous system
Normal distribution
Parasympathetic nervous system
Software
Velocity
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Summary:It is assumed that the Attention Deficit Hyperactivity Disorder is associated with the central autonomic dysregulation, however, the studies are rare. Analysis of pupillary light reflex represents a non-invasive tool to provide information related to the central autonomic regulation; thus, we aimed to evaluate potential disturbances in the central autonomic integrity using pupillary light reflex examination in Attention Deficit Hyperactivity Disorder. We have examined 20 children with Attention Deficit Hyperactivity Disorder (10 boys, 13.0±2.3 years) and 20 age/gender-matched healthy subjects. Pupillary light reflex was examined at rest for both eyes using Pupillometer PLR-2000 (NeurOptics, USA). Evaluated parameters were: diameter of the pupil before the application of light stimulus and after illumination at the peak of the constriction, the percentual change of the pupil diameter during constriction, average constriction velocity, maximum constriction velocity and average dilation velocity. We found significantly lower percentual change of the pupil diameter during constriction for both eyes in Attention Deficit Hyperactivity Disorder group compared to controls (right eye: -25.81±1.23 % vs. -30.32±1.31 %, p
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934589