Cough Reflex Sensitivity and Fractional Exhaled Nitric Oxide in Children With Asthma

Individual studies have suggested the utility of fractional exhaled nitric oxide (FeNO) measurement in detecting cough-variant asthma and eosinophilic bronchitis in patients with chronic cough. The aim of this study was to clarify a correlation of cough reflex sensitivity and fractional exhaled nitr...

Full description

Saved in:
Bibliographic Details
Published in:Physiological research 2020-12, Vol.69 (Suppl 3), p.S455-S461
Main Authors: KUNC, P, FABRY, J, ZATKO, T, GRENDAR, M, TATAR, M, PECOVA, R
Format: Article
Language:English
Subjects:
Aerosols
Age
Airway management
Asthma
Bronchitis
Capsaicin
Children
Children & youth
Cough
Inflammation
Leukocytes (eosinophilic)
Nitric oxide
Pediatrics
Respiratory diseases
Spirometry
Steroids
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Individual studies have suggested the utility of fractional exhaled nitric oxide (FeNO) measurement in detecting cough-variant asthma and eosinophilic bronchitis in patients with chronic cough. The aim of this study was to clarify a correlation of cough reflex sensitivity and fractional exhaled nitric oxide in asthmatic children. 25 children with asthma and 15 controls were submitted to cough reflex sensitivity measurement – capsaicin aerosol in doubling concentrations (from 0.61 to 1250 µmol/l) was inhaled by a single breath method. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Fractional exhaled nitric oxide (FeNO) measurement was included. Asthmatic children (11 boys and 14 girls, mean age 9±1 years) and control group (unconfirmed diagnosis of asthma) (6 boys and 9 girls, mean age 8±1 years) were included into the study. FeNO vs. C2 in asthma (Spearman´s rank correlation: -0.146, p=0.49); FENO vs. C5 in asthma (Spearman´s rank correlation: -0.777, p=0.71). We found that there is no correlation between cough reflex sensitivity and fractional exhaled nitric oxide either in children with asthma or in the control group.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934601