Incidence and Predictors of Progression to Chagas Cardiomyopathy: Long-Term Follow-Up of Trypanosoma cruzi -Seropositive Individuals
There are few contemporary cohorts of -seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with seropositivity. Participants were selected in blood banks at 2 Brazilian centers. C...
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Published in: | Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (19), p.1553-1566 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | There are few contemporary cohorts of
-seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with
seropositivity.
Participants were selected in blood banks at 2 Brazilian centers. Cases were defined as
-seropositive blood donors.
-seronegative controls were matched for age, sex, and period of donation. Patients with established Chagas cardiomyopathy were recruited from a tertiary outpatient service. Participants underwent medical examination, blood collection, ECG, and echocardiogram at enrollment (2008-2010) and at follow-up (2018-2019). The primary outcomes were all-cause mortality and development of cardiomyopathy, defined as the presence of a left ventricular ejection fraction |
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ISSN: | 0009-7322 1524-4539 |