Incidence and Predictors of Progression to Chagas Cardiomyopathy: Long-Term Follow-Up of Trypanosoma cruzi -Seropositive Individuals

There are few contemporary cohorts of -seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with seropositivity. Participants were selected in blood banks at 2 Brazilian centers. C...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2021-11, Vol.144 (19), p.1553-1566
Main Authors: Nunes, Maria Carmo P, Buss, Lewis F, Silva, Jose Luiz P, Martins, Larissa Natany A, Oliveira, Claudia Di Lorenzo, Cardoso, Clareci Silva, Brito, Bruno Oliveira de Figueiredo, Ferreira, Ariela Mota, Oliveira, Lea Campos, Bierrenbach, Ana Luiza, Fernandes, Fabio, Busch, Michael P, Hotta, Viviane Tiemi, Martinelli, Luiz Mario Baptista, Soeiro, Maria Carolina F Almeida, Brentegani, Adriana, Salemi, Vera M C, Menezes, Marcia M, Ribeiro, Antonio Luiz P, Sabino, Ester Cerdeira
Format: Article
Language:eng
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There are few contemporary cohorts of -seropositive individuals, and the basic clinical epidemiology of Chagas disease is poorly understood. Herein, we report the incidence of cardiomyopathy and death associated with seropositivity. Participants were selected in blood banks at 2 Brazilian centers. Cases were defined as -seropositive blood donors. -seronegative controls were matched for age, sex, and period of donation. Patients with established Chagas cardiomyopathy were recruited from a tertiary outpatient service. Participants underwent medical examination, blood collection, ECG, and echocardiogram at enrollment (2008-2010) and at follow-up (2018-2019). The primary outcomes were all-cause mortality and development of cardiomyopathy, defined as the presence of a left ventricular ejection fraction
ISSN:0009-7322
1524-4539