Pre-Transplant Solid Organ Malignancy and Organ Transplant Candidacy: A Consensus Expert Opinion Statement

Patients undergoing evaluation for solid organ transplantation often have a history of malignancy. Although the cancer has been treated in these patients, the benefits of transplantation needs to be balanced against the risk of tumor recurrence, especially in the setting of immunosuppression. Prior...

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Bibliographic Details
Published in:American journal of transplantation 2020-10, Vol.21 (2), p.460-474
Main Authors: Al-Adra, David P., Hammel, Laura, Roberts, John, Woodle, E. Steve, Levine, Deborah, Mandelbrot, Didier, Verna, Elizabeth, Locke, Jayme, D’Cunha, Jonathan, Farr, Maryjane, Sawinski, Deirdre, Agarwal, Piyush K., Plichta, Jennifer, Pruthi, Sandhya, Farr, Deborah, Carvajal, Richard, Walker, John, Zwald, Fiona, Habermann, Thomas, Gertz, Morie, Bierman, Philip, Dizon, Don S., Langstraat, Carrie, Al-Qauod, Talal, Eggener, Scott, Richgels, John P., Chang, George J., Geltzeiler, Cristina, Sapisochin, Gonzalo, Ricciardi, Rocco, Krupnick, Alexander Sasha, Kennedy, Cassie, Mohindra, Nisha, Foley, David P., Watt, Kymberly D.
Format: Article
Language:English
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Summary:Patients undergoing evaluation for solid organ transplantation often have a history of malignancy. Although the cancer has been treated in these patients, the benefits of transplantation needs to be balanced against the risk of tumor recurrence, especially in the setting of immunosuppression. Prior guidelines of when to transplant patients with a prior treated malignancy do not take in to account current staging, disease biology, or advances in cancer treatments. To develop contemporary recommendations, the American Society of Transplantation held a consensus workshop to perform a comprehensive review of current literature regarding cancer therapies, cancer stage specific prognosis, the kinetics of cancer recurrence, and the limited data on the effects of immunosuppression on cancer-specific outcomes. This document contains prognosis based on contemporary treatment and transplant recommendations for breast, colorectal, anal, urological, gynecological, non-small cell lung cancers. This conference and consensus documents aim to provide recommendations to assist in the evaluation of patients for solid organ transplantation given a history of a pre transplant malignancy.
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.16318