Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction

Purpose To explore the effects of 6-month systemic testosterone (T) administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD). Methods 81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2021-12, Vol.44 (12), p.2765-2776
Main Authors: Cipriani, S., Maseroli, E., Di Stasi, V., Scavello, I., Todisco, T., Rastrelli, G., Fambrini, M., Sorbi, F., Petraglia, F., Jannini, E. A., Maggi, M., Vignozzi, L.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Topical
Adult
Adverse events
Arousal
Blood flow
Blood glucose
Cholesterol
Clitoris - blood supply
Clitoris - diagnostic imaging
Clitoris - physiopathology
Doppler effect
Endocrinology
Estrogens
Estrogens - administration & dosage
Estrogens - adverse effects
Female
Gonadal Hormones - administration & dosage
Hemodynamics
Hemodynamics - drug effects
Hemoglobin
High density lipoprotein
Humans
Insulin
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Outcome Assessment, Health Care - methods
Sexual Dysfunction, Physiological - diagnosis
Sexual Dysfunction, Physiological - metabolism
Sexual Dysfunction, Physiological - physiopathology
Sexual Dysfunction, Physiological - therapy
Testosterone
Testosterone - administration & dosage
Testosterone - adverse effects
Treatment Outcome
Triglycerides
Ultrasonography, Doppler, Color - methods
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Summary:Purpose To explore the effects of 6-month systemic testosterone (T) administration on clitoral color Doppler ultrasound (CDU) parameters in women with female sexual dysfunction (FSD). Methods 81 women with FSD were retrospectively recruited. Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group), n  = 37; transdermal 2% T gel 300 mcg/day (T group), n  = 23; local estrogens (E group), n  = 12; combined therapy (T + E group), n  = 9. Patients underwent physical, laboratory, and genital CDU examinations at both visits and completed different validated questionnaires, including the Female Sexual Function Index (FSFI). Results At 6-month visit, T therapy significantly increased clitoral artery peak systolic velocity (PSV) when compared to both NH ( p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-021-01598-1