Maximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA

Introduction Maximal strength training (MST), performed with heavy loads (~ 90% of one repetition maximum; 1RM) and few repetitions, yields large improvements in efferent neural drive, skeletal muscle force production, and skeletal muscle efficiency. However, it is elusive whether neural adaptations...

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Bibliographic Details
Published in:European journal of applied physiology 2021-12, Vol.121 (12), p.3421-3430
Main Authors: Tøien, Tiril, Haglo, Håvard, Nyberg, Stian Kwak, Rao, Shalini Vasudev, Stunes, Astrid Kamilla, Mosti, Mats Peder, Wang, Eivind
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Physiological
Adenosine triphosphatase
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Biopsy
Ca2+-transporting ATPase
Calcium (reticular)
Evoked Potentials, Motor - physiology
Gene expression
Human Physiology
Humans
Male
Muscle Contraction - physiology
Muscle, Skeletal - innervation
Muscle, Skeletal - physiology
Musculoskeletal system
Occupational Medicine/Industrial Medicine
Original
Original Article
Protein expression
Proteins
Resistance Training
Sarcoplasmic reticulum
Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism
Skeletal muscle
Soleus muscle
Sports Medicine
Sports training
Strength training
Western blotting
Young Adult
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Summary:Introduction Maximal strength training (MST), performed with heavy loads (~ 90% of one repetition maximum; 1RM) and few repetitions, yields large improvements in efferent neural drive, skeletal muscle force production, and skeletal muscle efficiency. However, it is elusive whether neural adaptations following such high intensity strength training may be accompanied by alterations in energy-demanding muscular factors. Methods Sixteen healthy young males (24 ± 4 years) were randomized to MST 3 times per week for 8 weeks ( n  = 8), or a control group (CG; n  = 8). Measurements included 1RM and rate of force development (RFD), and evoked potentials recordings (V-wave and H-reflex normalized to M-wave (M) in the soleus muscle) applied to assess efferent neural drive to maximally contracting skeletal muscle. Biopsies were obtained from vastus lateralis and analyzed by western blots and real-time PCR to investigate the relative protein expression and mRNA expression of Sarcoplasmic Reticulum Ca 2+ ATPase (SERCA) 1 and SERCA2. Results Significant improvements in 1RM (17 ± 9%; p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-021-04807-0