The Influence of Perceived Dapivirine Vaginal Ring Effectiveness on Social Disclosure and Ring Adherence

We analyzed data from 1428 users of the dapivirine vaginal ring, who participated in the MTN-020/ASPIRE phase III trial and subsequent open-label extension MTN-025/HOPE trial, to examine relationships between perceived ring protection, social disclosures, and self-reported ring adherence. In HOPE, 7...

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Bibliographic Details
Published in:AIDS and behavior 2021-12, Vol.25 (12), p.4169-4179
Main Authors: Stoner, Marie C. D., Brown, Elizabeth R., Palanee-Phillips, Thesla, Mansoor, Leila E., Tembo, Tchangani, Nair, Gonasagrie, Akello, Carolyne, Seyama, Linly, Jeenarain, Nitesha, Naidoo, Logashvari, Mgodi, Nyaradzo, Hunidzarira, Portia, Chitukuta, Miria, van der Straten, Ariane
Format: Article
Language:English
Subjects:
Anti-HIV Agents - therapeutic use
Clinical trials
Contraceptive Devices, Female
Disclosure
Disease prevention
Female
Health behavior
Health Psychology
HIV
HIV Infections - drug therapy
HIV Infections - prevention & control
Human immunodeficiency virus
Humans
Infectious Diseases
Information dissemination
Medicine
Medicine & Public Health
Original Paper
Patient compliance
Protection
Public Health
Pyrimidines
Social interactions
Social support
Vagina
Womens health
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Summary:We analyzed data from 1428 users of the dapivirine vaginal ring, who participated in the MTN-020/ASPIRE phase III trial and subsequent open-label extension MTN-025/HOPE trial, to examine relationships between perceived ring protection, social disclosures, and self-reported ring adherence. In HOPE, 77% perceived the ring to be highly effective, and this view was associated with speaking: (a) to a greater number of people about the study, (b) with other participants, (c) to more people who were in favor of the ring, and (d) to more people whose opinions were valued. Reported adherence was not directly associated with perceived protection but was associated with disclosing to someone who was in favor of the ring. These findings suggest the importance of women’s internalized ideas about the protective benefits of the DVR in sharing information about the ring and the importance of social support on adherence.
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-021-03286-w