Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography

Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT’s structural signal with molecular imaging requires strategies to si...

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Bibliographic Details
Published in:Nano letters 2021-10, Vol.21 (20), p.8595-8601
Main Authors: Keahey, Pelham, Si, Peng, Razavi, Mohammad, Yu, Shangjie, Lippok, Norman, Villiger, Martin, Padera, Timothy P., de la Zerda, Adam, Bouma, Brett
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Gold
Letter
Mice
Nanoparticles
Tomography, Optical Coherence
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Summary:Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT’s structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral contrast (SC)-OCT measurements, we can distinguish signatures of different gold nanobipyramids (GNBPs) in lymphatic vessels from the surrounding tissue and blood vessels in live mouse models. This technique could well be extended to other anisotropic nanoparticle-based OCT contrast agents and presents significant progress toward enabling OCT molecular imaging.
ISSN:1530-6984
1530-6992
DOI:10.1021/acs.nanolett.1c02291