The bioinformatics analysis of quercetin in octagonal lotus for the screening of breast cancer MYC, CXCL10, CXCL11, and E2F1

Background Comprehensive bioinformatics analysis of the effective molecular screening of Podophyllum octagonal in breast cancer treatment by using network pharmacology. Methods We collected the active ingredients and target genes of Chinese medicine octagonal lotus through the Traditional Chinese Me...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2021, Vol.35, p.20587384211040903-20587384211040903
Main Authors: Ma, Yuexing, Peng, Zirong, Pan, Rongbin, Zhu, Zhixin, Meng, Xiaoqi, Hu, Huiming, Qiao, Xin, Huang, Xuening, Hou, Mengyu
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic
Berberidaceae
Bioinformatics
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - mortality
Chemokine CXCL10 - genetics
Chemokine CXCL11 - genetics
Chinese medicine
Computational Biology
Computer programs
CXCL10 protein
CXCL11 protein
E2F1 Transcription Factor - genetics
Female
Gene Expression Regulation, Neoplastic
Genes
Humans
Ingredients
Kaplan-Meier Estimate
Medicine, Chinese Traditional
Molecular Docking Simulation
Myc protein
Network Pharmacology
Original
Protein Interaction Maps
Proteins
Proto-Oncogene Proteins c-myc - genetics
Quercetin
Software
Survival analysis
Therapeutic targets
Traditional Chinese medicine
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Summary:Background Comprehensive bioinformatics analysis of the effective molecular screening of Podophyllum octagonal in breast cancer treatment by using network pharmacology. Methods We collected the active ingredients and target genes of Chinese medicine octagonal lotus through the Traditional Chinese Medicine System Pharmacology Analysis Platform (TCMSP); downloaded human protein annotation information on the protein database Uniport; and collected data from five databases: GeneCards, OMIM, PharmGkb, TDD, and DrugBank. Construct the practical ingredient-target gene data intersection to obtain the target gene-disease gene and draw the Venn diagram. We use Cytoscape 3.8.0 software to construct the effective component-target gene-disease gene network. The STRING database protein interaction (PPI) networks were erected, and we used Cytoscape 3.8.0 software to screen out its core sub-networks and hub gene networks. Through survival analysis, core genes and hub genes were screened to identify several key genes. We performed key target gene ontology (GO) analysis and gene interaction (KEGG) analysis, which were followed by molecular docking of the key active ingredients in the star anise corresponding to several key genes. Results 19 active ingredients, 444 drug targets, and 10,941 disease-related genes were obtained. The key active ingredient was quercetin. GO analysis revealed 2471 affected biological processes, and 167 pathways were obtained in KEGG enrichment analysis. Conclusion This study initially screened the key active ingredients of star aniseed lotus and analyzed key genes and several essential pathways. Traditional Chinese medicine is expected to provide new evidence and research ideas to prevent and treat breast cancer.
ISSN:2058-7384
0394-6320
2058-7384
DOI:10.1177/20587384211040903