Removal of Vasopressin cells from the Paraventricular Nucleus of the Hypothalamus enhances LPS-induced sickness behavior in mice

Vasopressin (AVP) cells in the paraventricular nucleus of the hypothalamus (PVN) are activated during sickness and project to multiple nuclei responsible for anxiety, social, and motivated behaviors affected during sickness, suggesting that these cells may play a role in sickness behaviors, typicall...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2020-12, Vol.33 (1), p.e12915-e12915
Main Authors: Whylings, Jack, Rigney, Nicole, de Vries, Geert J, Petrulis, Aras
Format: Article
Language:English
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Summary:Vasopressin (AVP) cells in the paraventricular nucleus of the hypothalamus (PVN) are activated during sickness and project to multiple nuclei responsible for anxiety, social, and motivated behaviors affected during sickness, suggesting that these cells may play a role in sickness behaviors, typically expressed as reduced mobility, increased anxiety, anhedonia, and social withdrawal. In this study, we selectively ablated AVP neurons in the PVN of male and female mice ( Mus musculus ) and induced sickness behavior via injection of bacterial lipopolysaccharide (LPS). We found that PVN AVP ablation increased the effects of LPS, specifically by further decreasing sucrose preference in males and females and decreasing the social preference of males, monitored within 24 hours of LPS injection. These results suggest that PVN AVP contributes to the change in motivated behaviors during sickness and may help promote recovery from infection.
ISSN:0953-8194
1365-2826
DOI:10.1111/jne.12915