Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis

Our hypothesis is that Secreted Frizzled-Related Protein 2 (sFPR2) is an important mechanism mediating ischemic cardioprotection, since it is the most upregulated gene in the third window of ischemic preconditioning. One week after permanent coronary artery occlusion (CAO), sFRP2 TG mice exhibited a...

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Bibliographic Details
Published in:Basic research in cardiology 2020-06, Vol.115 (4), p.48-48, Article 48
Main Authors: Vatner, Dorothy E., Oydanich, Marko, Zhang, Jie, Babici, Denis, Vatner, Stephen F.
Format: Article
Language:English
Subjects:
Angiogenesis
Blood flow
Cardiology
Collagen
Collagen (type I)
Collagen (type III)
Connective tissue growth factor
Coronary artery
Crosstalk
Endothelial cells
Fibroblast growth factors
Fibrosis
Frizzled protein
Frizzled-related protein
Growth hormone
Ischemia
Medicine
Medicine & Public Health
Myocardial ischemia
Myocytes
Occlusion
Original Contribution
Preconditioning
Proteins
Secreted frizzled-related protein 2
Signal transduction
Signaling
Vascular endothelial growth factor
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Summary:Our hypothesis is that Secreted Frizzled-Related Protein 2 (sFPR2) is an important mechanism mediating ischemic cardioprotection, since it is the most upregulated gene in the third window of ischemic preconditioning. One week after permanent coronary artery occlusion (CAO), sFRP2 TG mice exhibited a 49% higher LV ejection fraction and a 36% reduction in infarct size, p  
ISSN:0300-8428
1435-1803
DOI:10.1007/s00395-020-0808-0