Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake

Central vasopressin (AVP) has been implicated in the control of multiple behaviors, including social behavior, anxiety-like behavior, and sickness behavior. The extent to which the different AVP-producing cell groups contribute to regulating these behaviors has not been extensively investigated. Her...

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Bibliographic Details
Published in:Hormones and behavior 2021-07, Vol.133, p.104997-104997, Article 104997
Main Authors: Whylings, Jack, Rigney, Nicole, de Vries, Geert J., Petrulis, Aras
Format: Article
Language:English
Subjects:
Animals
Anxiety
Arginine Vasopressin - metabolism
Circadian Rhythm
Female
LPS
Male
Mice
Sickness
Social Behavior
Sucrose preference
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - metabolism
Vasopressin
Vasopressins - metabolism
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Summary:Central vasopressin (AVP) has been implicated in the control of multiple behaviors, including social behavior, anxiety-like behavior, and sickness behavior. The extent to which the different AVP-producing cell groups contribute to regulating these behaviors has not been extensively investigated. Here we test the role of AVP cells in the suprachiasmatic nucleus (SCN) in these behaviors by ablating these cells using viral-mediated, Cre-dependent caspase in male and female AVP-Cre + mice and Cre-controls. We compared anxiety and social behaviors, as well as sickness behaviors (lethargy, anhedonia (indexed by sucrose consumption), and changes in anxiety-like- and social behavior) induced via injection of bacterial lipopolysaccharide (LPS). We found that SCN AVP cell ablation increased anxiety-like behavior and sucrose consumption in both sexes, as well as increased urine marking by males in a non-social context, but did not alter behavioral responses to sickness. Our data suggest that SCN AVP does not strongly affect LPS-induced behavioral changes, but may contribute to anxiety-like behavior, and may play a role in ingestive reward/motivation and fluid intake. •SCN vasopressin cell ablation increases anxiety-like behavior.•SCN vasopressin cell ablation increases sucrose consumption.•Intensity of sickness behavior is not altered after SCN vasopressin cell deletion.
ISSN:0018-506X
1095-6867
DOI:10.1016/j.yhbeh.2021.104997