IL-23 orchestrating immune cell activation in arthritis

Abstract IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2021-10, Vol.60 (Supplement_4), p.iv4-iv15
Main Authors: Najm, Aurélie, McInnes, Iain B
Format: Article
Language:English
Subjects:
Animals
Arthritis - drug therapy
Arthritis - immunology
Arthritis - metabolism
Humans
Interleukin-23 - antagonists & inhibitors
Interleukin-23 - metabolism
Molecular Targeted Therapy
Supplement Papers
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Summary:Abstract IL-23 is a cytokine member of the IL-12 superfamily. These heterodimeric cytokines offer broad immune regulatory activity with potential effector function in inflammatory arthritis. IL-23 is a pro-inflammatory cytokine secreted by dendritic cells and macrophages. It plays a key role in both innate and adaptive immunity. By promoting and maintaining T cell differentiation into Th17 T cells, IL-23 is a key player in the pathogenesis of rheumatic diseases. Data from pre-clinical IL-23 knockout models show the major importance of IL-23 in development of arthritis. The induction and maintenance of type 17 cells, which secrete IL-17A and other pro-inflammatory cytokines, contributes to local synovial inflammation and skin inflammation in PsA, and perhaps in RA. Commensurate with this, therapeutic strategies targeting IL-23 have proven efficient in PsA in several studies, albeit not yet in RA.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keab266