Systemic immune-inflammation index is a promising non-invasive biomarker for predicting the survival of urinary system cancers: a systematic review and meta-analysis

Systemic immune-inflammation index (SII) has been reported in numerous studies to effectively predict the survival outcomes of urinary system cancers; however no agreement has been reached. This meta-analysis aimed to explore the prognostic significance of pre-treatment SII in tumours of the urinary...

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Bibliographic Details
Published in:	Annals of medicine (Helsinki) 2021-01, Vol.53 (1), p.1827-1838
Main Authors:	Li, Xing, Gu, Lijiang, Chen, Yuhang, Chong, Yue, Wang, Xinyang, Guo, Peng, He, Dalin
Format:	Article
Language:	eng
Subjects:	Biomarkers - blood Humans Inflammation - diagnosis meta-analysis Nephrology & Urology Predictive Value of Tests Prognosis Proportional Hazards Models Review systemic immune-inflammation index Urinary system cancers Urologic Neoplasms - blood Urologic Neoplasms - immunology Urologic Neoplasms - mortality
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Summary:	Systemic immune-inflammation index (SII) has been reported in numerous studies to effectively predict the survival outcomes of urinary system cancers; however no agreement has been reached. This meta-analysis aimed to explore the prognostic significance of pre-treatment SII in tumours of the urinary system. Relevant published articles were selected from Web of Science, PubMed, Embase, and the Cochrane Library up to 30 August 2020. The hazard ratios (HRs) with 95% confidence intervals (CIs) were computed to estimate the associations of pre-treatment SII with overall survival (OS), progression-free survival (PFS), cancer-specific survival (CSS) in urinary system cancers. 13 papers were included in our meta-analysis. From the combined data, we found that a high pre-treatment SII indicated a markedly worse OS (HR = 1.98; 95% CI: 1.75-2.23; p
ISSN:	0785-3890 1365-2060