Validation of novel 3‐dimensional quantitative coronary angiography based software to calculate fractional flow reserve post stenting

Objectives To validate novel dedicated 3D‐QCA based on the software to calculate post PCI vessel‐FFR (vFFR) in a consecutive series of patients, to assess the diagnostic accuracy, and to assess inter‐observer variability. Background Low post percutaneous coronary intervention (PCI) fractional flow r...

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Published in:Catheterization and cardiovascular interventions 2021-10, Vol.98 (4), p.671-677, Article ccd.29311
Main Authors: Masdjedi, Kaneshka, Zandvoort, Laurens JC, Balbi, Matthew M, Nuis, Rutger‐Jan, Wilschut, Jeroen, Diletti, Roberto, Jaegere, Peter P.T., Zijlstra, Felix, Van Mieghem, Nicolas M, Daemen, Joost
Format: Article
Language:English
Subjects:
Accuracy
Aged
Angina
Angiography
Aorta
Cohort Studies
Computer programs
Coronary Angiography
Coronary artery
Coronary Artery Disease
Coronary Vessels - diagnostic imaging
Coronary Vessels - surgery
fractional flow reserve
Fractional Flow Reserve, Myocardial
Humans
Male
Middle Aged
Myocardial infarction
Original Studies
Percutaneous Coronary Intervention - adverse effects
Predictive Value of Tests
quantitative coronary angiography
Retrospective Studies
Software
Stents
Treatment Outcome
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Summary:Objectives To validate novel dedicated 3D‐QCA based on the software to calculate post PCI vessel‐FFR (vFFR) in a consecutive series of patients, to assess the diagnostic accuracy, and to assess inter‐observer variability. Background Low post percutaneous coronary intervention (PCI) fractional flow reserve (FFR) predicts future adverse cardiac events. However, FFR assessment requires the insertion of a pressure wire in combination with the use of a hyperemic agent. Methods FAST POST study is an observational, retrospective, single‐center cohort study. One hundred patients presenting with stable angina or non ST‐elevation myocardial infarction, who underwent post PCI FFR assessment using a dedicated microcatheter were included. Two orthogonal angiographic projections were acquired to create a 3D reconstruction of the coronary artery using the CAAS workstation 8.0. vFFR was subsequently calculated using the aortic root pressure. Results Mean age was 65±12 years and 70% were male. Mean microcatheter based FFR and vFFR were 0.91±0.07 and 0.91±0.06, respectively. A good linear correlation was found between FFR and vFFR (r = 0.88; p 
ISSN:1522-1946
1522-726X
1522-726X
DOI:10.1002/ccd.29311