A predictive model for preterm babies born < 30 weeks gestational age who will not attain full oral feedings

Develop a model to predict gastrostomy tube (GT) for feeding at discharge in infants born < 30 weeks' (w) gestational age (GA). A single-center retrospective study at academic NICU. Total of 391 (78 GT, 313 non-GT) infants < 30 w GA admitted in 2015-2018 split into test (15-16) and valida...

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Bibliographic Details
Published in:Journal of perinatology 2022-01, Vol.42 (1), p.126-131
Main Authors: Gehle, Daniel B, Chapman, Alison, Gregoski, Mathew, Brunswick, Meghan, Anderson, Emily, Ramakrishnan, Viswanathan, Muhammad, Lutfiyya N, Head, William, Lesher, Aaron P, Ryan, Rita M
Format: Article
Language:English
Subjects:
Age
Discharge
Enterocolitis
Gastrostomy
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
Infants
Necrotizing enterocolitis
Ostomy
Prediction models
Premature babies
Regression analysis
Retrospective Studies
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Summary:Develop a model to predict gastrostomy tube (GT) for feeding at discharge in infants born < 30 weeks' (w) gestational age (GA). A single-center retrospective study at academic NICU. Total of 391 (78 GT, 313 non-GT) infants < 30 w GA admitted in 2015-2018 split into test (15-16) and validation (17-18) cohorts. Classification and regression tree analysis was used to identify predictive factors for GT. Several factors were associated with GT requirements. Four factors included in the model were postmenstrual age (PMA) at first oral feeding, birth GA, high-frequency ventilation exposure, necrotizing enterocolitis stage II/III. Area under the receiver operator characteristic curve was 0.944 in the test cohort, 0.815 in the validation cohort. Implementation plan based on the model was developed. We developed a predictive model to risk-stratify infants born < 30 w GA for failing full oral feeding. We hope implementation at 38 w PMA will result in earlier placement of needed GT and discharge.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-021-01219-y