Fluorine-18 fluorodeoxyglucose positron emission tomography/ computed tomography in hodgkin's lymphoma: Diagnostic challenge during COVID vaccination

Benign metabolic uptake on fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is not uncommonly seen after immunization. We report a case of 30-year-old man with Hodgkin's lymphoma who underwent two cycles of chemotherapy. Interim 18F-FDG PET/computed tomography demonstra...

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Bibliographic Details
Published in:Indian journal of nuclear medicine 2021-07, Vol.36 (3), p.343-346
Main Authors: Usmani, Sharjeel, Al-Ramadhan, Fatma, Al-Kandari, Fareeda, Ahmed, Najeeb
Format: Article
Language:English
Subjects:
Cancer
Chemotherapy
Computed tomography
COVID-19 vaccines
CT imaging
Diagnosis
Diagnostic imaging
Fluorides
Fluorine
Fluorine isotopes
Immunization
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Lymphatic system
Lymphoma
Lymphomas
Metabolism
Muscles
Positron emission
Tomography
Vaccination
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Summary:Benign metabolic uptake on fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is not uncommonly seen after immunization. We report a case of 30-year-old man with Hodgkin's lymphoma who underwent two cycles of chemotherapy. Interim 18F-FDG PET/computed tomography demonstrated complete metabolic response of prior hypermetabolic bilateral supraclavicular and mediastinal lymph nodes. Although multiple new normal-sized hypermetabolic left axillary and subpectoral lymph nodes are noted, relevant history revealed COVID vaccine 7 days prior scan with mild FDG uptake at the left deltoid muscle. These new findings at the left axilla are likely related to recent vaccination. 18F-FDG PET uptake in the lymph nodes is not so uncommon after immunization; relevant history is very important especially in the phase of massive immunization to avoid false interpretation.
ISSN:0972-3919
0974-0244
DOI:10.4103/ijnm.ijnm_31_21