Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery

Abstract Summary Previous attempts in cardiac bioengineering have failed to provide tissues for cardiac regeneration. Recent advances in 3-dimensional bioprinting technology using prevascularized myocardial microtissues as ‘bioink’ have provided a promising way forward. This review guides the reader...

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Bibliographic Details
Published in:European journal of cardio-thoracic surgery 2020-09, Vol.58 (3), p.500-510
Main Authors: Roche, Christopher D, Brereton, Russell J L, Ashton, Anthony W, Jackson, Christopher, Gentile, Carmine
Format: Article
Language:English
Subjects:
Review
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Summary:Abstract Summary Previous attempts in cardiac bioengineering have failed to provide tissues for cardiac regeneration. Recent advances in 3-dimensional bioprinting technology using prevascularized myocardial microtissues as ‘bioink’ have provided a promising way forward. This review guides the reader to understand why myocardial tissue engineering is difficult to achieve and how revascularization and contractile function could be restored in 3-dimensional bioprinted heart tissue using patient-derived stem cells.
ISSN:1010-7940
1873-734X
DOI:10.1093/ejcts/ezaa093