Wound healing applications of creams and “smart” hydrogels

Although superficial wounds are often easy to treat for healthy individuals, there are some more severe types of wounds (burns, ulcers, diabetic wounds, etc.) that are a challenge for clinicians. A good therapeutic result is based on the delivery of a treatment at the right time, for the right patie...

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Bibliographic Details
Published in:Experimental dermatology 2021-09, Vol.30 (9), p.1218-1232
Main Authors: Stan, Diana, Tanase, Cristiana, Avram, Marioara, Apetrei, Roxana, Mincu, Nicolae‐Bogdan, Mateescu, Andreea Lorena, Stan, Dana
Format: Article
Language:English
Subjects:
Administration, Topical
Combined Modality Therapy
Controlled release
creams
Diabetes mellitus
Dressings
Humans
Hydrogels
Patients
Review
Skin Cream
smart hydrogels
Ulcers
wound classification
wound dressing
Wound healing
Wound Healing - drug effects
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Summary:Although superficial wounds are often easy to treat for healthy individuals, there are some more severe types of wounds (burns, ulcers, diabetic wounds, etc.) that are a challenge for clinicians. A good therapeutic result is based on the delivery of a treatment at the right time, for the right patient. Our goal was to sum up useful knowledge regarding wound healing and wound treatments, based on creams and hydrogels with various active ingredients. We concluded that both preparations have application in preventing infections and promoting healing, but their efficacy is clearly conditioned by the type, depth, severity of the wound and patient profile. However, due to their superior versatility and capability of maintaining the integrity and functionality of the active ingredient, as well as it is controlled release at site, hydrogels are more suited for incorporating different active ingredients. New wound healing devices can combine smart hydrogel dressings with physical therapies to deliver a more efficient treatment to patients if the indications are appropriate. There are a series of factors (mechanical, chemical, radiation, thermal, metabolic etc.) that can disrupt the skin integrity and/or functions and lead to skin wounds. There are many treatment options that can help restore skin barrier, among which hydrogels and creams.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.14396