MOTHER Study: A Multicenter Observational, Retrospective Study to Determine Coorelation Between Physical CHaracteristics and Ovarian REserve Markers in Sub-feRtile Women

Background The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which...

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Published in:Journal of obstetrics and gynaecology of India 2021-10, Vol.71 (5), p.510-521
Main Authors: Ayyavoo, Charmila, Baxi, Asha, Mandrupkar, Gorakh, Malik, Sonia, Kannan, Jayam, Goenka, Deepak, Kumar, Nagesh, Singh, Monica, Kulkarni, Sharda, Agarwal, Kanchan Murarka, Baxi, Sonam
Format: Article
Language:English
Subjects:
Gynecology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
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Summary:Background The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India. Methods In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected. Results Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation. Conclusion Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.
ISSN:0971-9202
0975-6434
DOI:10.1007/s13224-020-01410-9