Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study)

Aims/hypothesis The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide in all ethnic groups. Low vitamin B 12 and low/high folate levels may contribute to GDM risk, but there is conflicting evidence. Our aim is to assess the relationships of early pregnancy vitamin B 12 and fo...

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Published in:Diabetologia 2021-10, Vol.64 (10), p.2170-2182
Main Authors: Saravanan, Ponnusamy, Sukumar, Nithya, Adaikalakoteswari, Antonysunil, Goljan, Ilona, Venkataraman, Hema, Gopinath, Amitha, Bagias, Christos, Yajnik, Chittaranjan S., Stallard, Nigel, Ghebremichael-Weldeselassie, Yonas, Fall, Caroline H. D.
Format: Article
Language:English
Subjects:
Cohort analysis
Diabetes mellitus
Ethnicity
Folic acid
Gestation
Gestational diabetes
Glucose
Glucose metabolism
Health risks
Human Physiology
Hyperglycemia
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Minority & ethnic groups
Parity
Plasma
Pregnancy
Smoking
Statistical analysis
Vitamin B
Vitamin B12
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Summary:Aims/hypothesis The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide in all ethnic groups. Low vitamin B 12 and low/high folate levels may contribute to GDM risk, but there is conflicting evidence. Our aim is to assess the relationships of early pregnancy vitamin B 12 and folate levels with the risk of GDM status at 26–28 weeks of gestation. Methods This was a prospective, multi-centre, multi-ethnic cohort study ( n  = 4746) in the UK. Participants who were eligible to be selectively screened as per the National Institute for Health and Care Excellence (NICE) criteria were included in the study. Results GDM prevalence was 12.5% by NICE and 14.7% by International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. Folate deficiency (1.3%) was rare but B 12 insufficiency (42.3% at
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-021-05510-7