Comparative analysis of the association between various serum vitamin D biomarkers and sarcopenia

Background Vitamin D status is associated with muscle strength and maintenance of muscle fibers. However, which serum vitamin D biomarker better reflects sarcopenia remains unclear. The aim of this study was to investigate associations between various serum vitamin D biomarkers (total 25‐hydroxy vit...

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Published in:Journal of clinical laboratory analysis 2021-09, Vol.35 (9), p.e23946-n/a
Main Authors: Yoo, Jun‐Il, Chung, Hye Jin, Kim, Bo Gyu, Jung, Youn‐Kwan, Baek, Kyung‐Wan, Song, Myung‐Geun, Cho, Min‐Chul
Format: Article
Language:English
Subjects:
Aged
Bioavailability
bioavailable 25(OH)D
Biomarkers
Biomarkers - blood
Case-Control Studies
Comparative analysis
Enzymes
Female
Follow-Up Studies
Humans
Liquid chromatography
Male
Mass spectroscopy
Muscle strength
Musculoskeletal system
Older people
Prognosis
Proteins
Sarcopenia
Sarcopenia - blood
Sarcopenia - diagnosis
Vitamin D
Vitamin D - blood
Vitamin D - classification
vitamin D binding protein
Vitamin deficiency
Vitamins - blood
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Summary:Background Vitamin D status is associated with muscle strength and maintenance of muscle fibers. However, which serum vitamin D biomarker better reflects sarcopenia remains unclear. The aim of this study was to investigate associations between various serum vitamin D biomarkers (total 25‐hydroxy vitamin D [25(OH)D], bioavailable 25(OH)D, 24,25‐dihydroxyvitamin D [24,25(OH)2D], and vitamin D metabolite ratio [VMR]) and sarcopenia. Methods The data for 83 hip fracture patients were finally included in the analysis. Sarcopenia was defined according to the Asia Working Group for Sarcopenia (AWGS) criteria. Measurements of 24,25(OH)2D and 25(OH)D were made using solid‐phase extraction (SPE) and subsequent liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Vitamin D binding protein (VDBP) concentration was measured using an enzyme‐linked immunosorbent assay. The VMR was calculated by dividing serum 24,25(OH)2D by serum 25(OH)D and then multiplying by 100. Based on total 25(OH)D, VDBP, and albumin concentrations, bioavailable 25(OH)D concentrations were calculated using the equations from the other previous studies. Results Bioavailable 25(OH)D levels were significantly (p = 0.030) decreased in the sarcopenia group compared with the non‐sarcopenia group. Results of ROC analysis for the diagnosis of sarcopenia using serum level of bioavailable of 25(OH)D revealed that the cutoff point for bioavailable 25(OH)D was 1.70 ng/ml (AUC = 0.649, p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.23946