Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie

Abstract Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird’s adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived antibodies display less undesired cross-react...

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Bibliographic Details
Published in:Biospektrum 2021-09, Vol.27 (5), p.500-504
Main Authors: Elter, Adrian, Bogen, Jan P., Habermann, Jan, Kolmar, Harald
Format: Article
Language:ger ; eng
Subjects:
Wissenschaft Special
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Summary:Abstract Due to the large evolutionary distance between birds (Aves) und humans, immunization of chickens with human proteins results in a strong response of the bird’s adaptive immune system to proteins of mammalian origin. Additionally, chicken-derived antibodies display less undesired cross-reactivity in analytical setups than conventional rodent-derived antibodies. Due to these features as well as the facile amplification of antibody-coding genes, chicken-derived antibodies emerged as promising molecules for the immunotherapy and various biotechnological applications.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-021-1623-3