The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors' medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate E...

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Published in:	Biomolecules & biomedicine 2021-10, Vol.21 (5), p.549-554
Main Authors:	Ocak, Birol, Atalay, Fatma Öz, Sahin, Ahmet Bilgehan, Ozsen, Mine, Dakiki, Bahar, Türe, Seray, Mesohorli, Merve, Odman, Hikmet Utku, Tanrıverdi, Özgür, Ocakoğlu, Gökhan, Bayrak, Mehmet, Ozan, Hakan, Demiröz, Candan, Sali, Seda, Orhan, Sibel Oyucu, Deligönül, Adem, Cubukcu, Erdem, Evrensel, Türkkan
Format:	Article
Language:	eng
Subjects:	Adult Aged Biomarkers, Tumor - blood Cancer Carcinoma, Squamous Cell - pathology Case-Control Studies Cell differentiation Development and progression Endometrial cancer Endometrial Neoplasms - pathology endometrioid endometrial carcinoma Female Health aspects Humans Ki-67 Ki-67 antigen Ki-67 Antigen - blood Low-intermediate risk Middle Aged Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence, Local - epidemiology Neoplasm Staging Physiological aspects Prognosis recurrence Relapse Retrospective Studies Risk Factors squamous differentiation
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Summary:	Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors' medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were Stage 1A, and 4 patients (23.5%) were Stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p > 0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p
ISSN:	1512-8601 2831-0896 1840-4812 2831-090X