Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank

Physical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and malignant melanoma. We examined physical activity, grip strength and sedentary behaviour in...

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Bibliographic Details
Published in:British journal of cancer 2021-08, Vol.125 (4), p.593-600
Main Authors: Weber, Andrea, Leitzmann, Michael F, Sedlmeier, Anja M, Baurecht, Hansjörg, Jochem, Carmen, Haferkamp, Sebastian, Baumeister, Sebastian E
Format: Article
Language:English
Subjects:
Adult
Aged
Biobanks
Biological Specimen Banks
Exercise
Exercise - statistics & numerical data
Female
Hand Strength - physiology
Humans
Incidence
Male
Melanoma
Melanoma - epidemiology
Melanoma - etiology
Middle Aged
Physical activity
Prospective Studies
Risk Factors
Sedentary Behavior
Skin cancer
Ultraviolet radiation
United Kingdom - epidemiology
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Summary:Physical activity has been positively related to malignant melanoma. However, that association may be confounded by ultraviolet radiation (UV), a variable closely related to both outdoor physical activity and malignant melanoma. We examined physical activity, grip strength and sedentary behaviour in relation to risk of malignant melanoma, accounting for relevant confounders using data from a prospective cohort study. In 350,512 UK Biobank participants aged 38-73 years at baseline, physical activity was assessed with a modified version of the International Physical Activity Questionnaire Short Form, grip strength was measured with a hand dynamometer, and sedentary behaviour was recorded with three specific questions. Multivariable hazard ratios (HR) and corresponding 95% confidence intervals (CI) were estimated using Cox proportional hazards regression. During 7 years of follow-up, 1239 incident malignant melanoma diagnoses were recorded. Physical activity and sedentary behaviour were unrelated to malignant melanoma (HRs 1.01 (95% CI 0.95-1.07) and 1.04 (95% CI 0.97-1.12), respectively), and the initially positive association with grip strength in the basic model (HR 1.23, 95% CI 1.08-1.40) was attenuated after full adjustment (HR 1.10, 95% CI 0.96-1.26). Physical activity, grip strength and sedentary behaviour are not associated with malignant melanoma risk.
ISSN:0007-0920
1532-1827
DOI:10.1038/s41416-021-01443-5