Successful treatment of restless leg syndrome with the traditional herbal medicines Dangguijakyak-san and Shihogyeji-tang: A case report (CARE-compliant)

Dopamine replacement is currently the standard treatment for restless leg syndrome (RLS); however, various adverse effects are associated with long-term therapy, and the benefits disappear upon discontinuation. To overcome these limitations, interest in traditional East Asian medicine has increased....

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-08, Vol.100 (31), p.e26800-e26800
Main Authors: Seo, Yuna, Jin, Chul, Jang, Bo-Hyoung, Jeon, Jin Pyeong, Lee, Ye-Seul, Yang, Seung-Bo, Jung, Woo-Sang, Moon, Sang-Kwan, Cho, Ki-Ho, Kwon, Seungwon
Format: Article
Language:English
Subjects:
Aged
Clinical Case Report
Drugs, Chinese Herbal - administration & dosage
Female
Humans
Medicine, East Asian Traditional - methods
Restless Legs Syndrome - complications
Restless Legs Syndrome - diagnosis
Restless Legs Syndrome - psychology
Restless Legs Syndrome - therapy
Sleep Initiation and Maintenance Disorders - etiology
Sleep Initiation and Maintenance Disorders - physiopathology
Sleep Initiation and Maintenance Disorders - prevention & control
Time
Treatment Outcome
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Summary:Dopamine replacement is currently the standard treatment for restless leg syndrome (RLS); however, various adverse effects are associated with long-term therapy, and the benefits disappear upon discontinuation. To overcome these limitations, interest in traditional East Asian medicine has increased. A 72-year-old Asian woman originally admitted for an intracerebral hemorrhage presented with complaints of an unpleasant sensation throughout the body that appeared at night. The patient was diagnosed with chronic persistent RLS based on the 2012 Revised International Restless Leg Syndrome Study Group Diagnostic Criteria. The patient was treated with extracts of the traditional herbal medicines Dangguijakyak-san (DS) and Shihogyeji-tang (ST). After 47 days of therapy, all herbal medicines were discontinued, and symptoms had not returned by the last follow-up 244 days after the initial treatment. One week after initiating herbal treatment with DS and ST, the RLS symptoms began to improve, and the total hours of sleep had increased from 2 to 9 hours by day 21, with a Korean version of the international restless legs scale score of 11 points. On day 36, ST was discontinued, given the continued improvement of symptoms. On day 47, symptoms had disappeared (Korean version of the international restless legs scale score: 0), and sleep disturbances caused by RLS had completely resolved. After day 47, DS was also discontinued. There were no adverse effects associated with the administration of DS and ST, and the symptoms had not recurred by the last follow-up on day 244. In this case, RLS related symptoms, which had been present for approximately 60 years, were improved using only the traditional herbal medicines DS and ST (without dopamine replacement), and no symptoms recurred for 244 days. This case suggests that if replacement therapy is difficult or not desired, herbal medicinal therapies may be an effective alternative. This also suggests that the effect of herbal medicine on RLS might be semi-permanent. Further investigations, including clinical trials, are needed to confirm these effects.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000026800