Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome

Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neurora...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1998-03, Vol.19 (3), p.415-417
Main Authors: Ito, Y, Arahata, Y, Goto, Y, Hirayama, M, Nagamutsu, M, Yasuda, T, Yanagi, T, Sobue, G
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - adverse effects
Biological and medical sciences
Brain Diseases - chemically induced
Brain Diseases - diagnosis
Case Reports
Cisplatin - adverse effects
Diagnosis, Differential
Drug toxicity and drugs side effects treatment
Humans
Leukoencephalopathy, Progressive Multifocal - diagnosis
Magnetic Resonance Imaging
Male
Medical sciences
Pharmacology. Drug treatments
Toxicity: nervous system and muscle
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Description
Summary:Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.
ISSN:0195-6108
1936-959X