Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity

The association of brown adipose tissue (BAT) and body fat distribution and their combined effects on metabolic health in humans remains unknown. Here, we retrospectively identify individuals with and without BAT on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomogra...

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Bibliographic Details
Published in:Cell reports. Medicine 2021-07, Vol.2 (7), p.100332-100332, Article 100332
Main Authors: Wibmer, Andreas G., Becher, Tobias, Eljalby, Mahmoud, Crane, Audrey, Andrieu, Pamela Causa, Jiang, Caroline S., Vaughan, Roger, Schöder, Heiko, Cohen, Paul
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - diagnostic imaging
Adipose Tissue, Brown - physiology
Adiposity - physiology
Body Fat Distribution
brown adipose tissue
brown fat
Cohort Studies
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnostic imaging
Diabetes Mellitus, Type 2 - pathology
Fatty Liver - complications
Fatty Liver - diagnostic imaging
Female
Fluorodeoxyglucose F18
glucose metabolism
hepatic steatosis
Humans
lipid metabolism
Liver - diagnostic imaging
Liver - pathology
Male
metabolic health
Metabolome
Middle Aged
Multivariate Analysis
Positron Emission Tomography Computed Tomography
subcutaneous fat
type 2 diabetes mellitus
visceral fat
visceral obesity
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Summary:The association of brown adipose tissue (BAT) and body fat distribution and their combined effects on metabolic health in humans remains unknown. Here, we retrospectively identify individuals with and without BAT on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and assemble a propensity score-matched study cohort to compare body fat distribution and determine its role in mediating the benefits of brown fat. We find that BAT is associated with lower amounts of visceral adipose tissue and higher amounts of subcutaneous adipose tissue, resulting in less central obesity. In addition, BAT is independently associated with lower blood glucose and white blood cell count, improved lipids, lower prevalence of type 2 diabetes mellitus, and decreased liver fat accumulation. These observations are most prominent in individuals with central obesity. Our results support a role of BAT in protection from visceral adiposity and improved metabolic health. [Display omitted] Brown adipose tissue is associated with more subcutaneous and less visceral fatBrown adipose tissue is associated with health independent of fat distributionBrown adipose tissue is associated with less liver fat and type 2 diabetesBrown adipose tissue is most beneficial in individuals with central obesity Wibmer et al. report that brown adipose tissue is associated with a healthier body fat distribution and less central obesity and also associated independently with surrogate parameters of metabolic health and decreased liver fat accumulation. These observations are most prominent in individuals with central obesity.
ISSN:2666-3791
2666-3791
DOI:10.1016/j.xcrm.2021.100332