Non-REM Apnea and Hypopnea Duration Varies across Population Groups and Physiologic Traits

Symptoms and morbidities associated with obstructive sleep apnea (OSA) vary across individuals and are not predicted by the apnea-hypopnea index (AHI). Respiratory event duration is a heritable trait associated with mortality that may further characterize OSA. We evaluated how hypopnea and apnea dur...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2021-05, Vol.203 (9), p.1173-1182
Main Authors: Borker, Priya V, Reid, Michelle, Sofer, Tamar, Butler, Matthew P, Azarbarzin, Ali, Wang, Heming, Wellman, Andrew, Sands, Scott A, Redline, Susan
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Algorithms
Arousal
Body Mass Index
Cohort Studies
Epidemiology
Ethnicity - statistics & numerical data
Female
Genotype & phenotype
Humans
Male
Middle Aged
Original
Pharynx - physiopathology
Physiology
Polysomnography
Regression analysis
Respiratory diseases
Respiratory Rate
Risk Factors
Sex Factors
Sleep apnea
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - epidemiology
Sleep Apnea, Obstructive - physiopathology
Sleep, REM - physiology
Time Factors
Whites - statistics & numerical data
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Summary:Symptoms and morbidities associated with obstructive sleep apnea (OSA) vary across individuals and are not predicted by the apnea-hypopnea index (AHI). Respiratory event duration is a heritable trait associated with mortality that may further characterize OSA. We evaluated how hypopnea and apnea durations in non-REM (NREM) sleep vary across demographic groups and quantified their associations with physiological traits (loop gain, arousal threshold, circulatory delay, and pharyngeal collapsibility). Data were analyzed from 1,546 participants from the Multi-Ethnic Study of Atherosclerosis with an AHI ≥5. Physiological traits were derived using a validated model fit to the polysomnographic airflow signal. Multiple linear regression models were used to evaluate associations of event duration with demographic and physiological factors. Participants had a mean age ± SD of 68.9 ± 9.2 years, mean NREM hypopnea duration of 21.73 ± 5.60, and mean NREM apnea duration of 23.87 ± 7.44 seconds. In adjusted analyses, shorter events were associated with younger age, female sex, higher body mass index (  
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.202005-1808OC