Development and validation of a prognostic score for long‐term transplant‐free survival in autoimmune hepatitis type 1

Background No prognostic score is currently available for long‐term survival in autoimmune hepatitis (AIH) patients. Objective The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. Methods The prognostic score was developed using uni‐ & multivar...

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Published in:United European gastroenterology journal 2021-07, Vol.9 (6), p.662-671
Main Authors: Biewenga, Maaike, Verhelst, Xavier P.D.M.J., Baven‐Pronk, Martine A.M.C., Putter, Hein, Berg, Aad P., Nieuwkerk, Karin C.M.J., Buuren, Henk R., Bouma, Gerd, Boer, Ynte S., Simoen, Cedric, Colle, Isabelle, Schouten, Jeoffrey, Sermon, Filip, Steenkiste, Christophe, Vlierberghe, Hans, Meer, Adriaan J., Nevens, Frederik, Hoek, Bart
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
AIH
autoimmune hepatitis
autoimmune liver disease
Belgium - epidemiology
Biopsy
Child
Child, Preschool
Clinical trials
Cohort Studies
Decision Support Techniques
Disease Progression
Disease-Free Survival
Ethnicity
Female
Hepatitis
Hepatitis, Autoimmune - complications
Hepatitis, Autoimmune - mortality
Hepatitis, Autoimmune - therapy
Hepatobiliary
Humans
Liver cancer
Liver cirrhosis
Liver Cirrhosis - etiology
Liver Cirrhosis - mortality
liver transplantation
Liver Transplantation - statistics & numerical data
Liver transplants
long‐term survival
Male
Medical prognosis
Middle Aged
Mortality
Multivariate Analysis
Netherlands - epidemiology
Original
Outpatient care facilities
Patients
Prognosis
prognostic score
Proportional Hazards Models
Remission (Medicine)
Reproducibility of Results
Risk Assessment
Risk Factors
risk stratification
Statistical analysis
Steroids
Survival analysis
Time Factors
transplant‐free survival
validation
Variables
White people
Young Adult
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Summary:Background No prognostic score is currently available for long‐term survival in autoimmune hepatitis (AIH) patients. Objective The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. Methods The prognostic score was developed using uni‐ & multivariate Cox regression in a 4‐center Dutch cohort and validated in an independent 6‐center Belgian cohort. Results In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow‐up 118 months; interquartile range 60–202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p 
ISSN:2050-6406
2050-6414
DOI:10.1002/ueg2.12112