TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling

Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo signaling pathway; it was suggested to be involved in the regulation of bone homeostasis. However, the ex...

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Bibliographic Details
Published in:Bone Research 2021-07, Vol.9 (1), p.33-33
Main Authors: Yang, Wanlei, Lu Xuanyuan, Zhang, Tan, Han, Weiqi, Li, Jianlei, He, Wei, Jia Yewei, Zhao Kangxian, An, Qin, Yu, Qian
Format: Article
Language:English
Subjects:
Osteoporosis
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Summary:Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo signaling pathway; it was suggested to be involved in the regulation of bone homeostasis. However, the exact role of TAZ in osteoclasts has not yet been established. In this study, we demonstrated that global knockout and osteoclast-specific knockout of TAZ led to a low-bone mass phenotype due to elevated osteoclast formation, which was further evidenced by in vitro osteoclast formation assays. Moreover, the overexpression of TAZ inhibited RANKL-induced osteoclast formation, whereas silencing of TAZ reduced it. Mechanistically, TAZ bound to TGF-activated kinase 1 (TAK1) and reciprocally inhibited NF-κB signaling, suppressing osteoclast differentiation. Collectively, our findings highlight an essential role of TAZ in the regulation of osteoclastogenesis in osteoporosis and its underlying mechanism.
ISSN:2095-4700
2095-6231
DOI:10.1038/s41413-021-00151-3