Bone Density Changes Following Radiotherapy to Vertebral Metastases

Introduction Patients have increasing longevity and time for bone healing following radiotherapy (RT) for treatment of bone metastases (BM). Attempts to assess the treatment response of bone metastases have been either limited or heavily subjective. Our goal was to try to quantitate cancer-involved...

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Published in:Curēus (Palo Alto, CA) CA), 2021-06, Vol.13 (6), p.e15417-e15417
Main Authors: Jensen, Garrett L, Gaddipati, Ravi, Hammonds, Kendall P, Morrow, Andrew, Swanson, Gregory P
Format: Article
Language:English
Subjects:
Oncology
Radiation Oncology
Radiology
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Summary:Introduction Patients have increasing longevity and time for bone healing following radiotherapy (RT) for treatment of bone metastases (BM). Attempts to assess the treatment response of bone metastases have been either limited or heavily subjective. Our goal was to try to quantitate cancer-involved bone changes after RT using changes in bone mineral density (BMD) from computer tomographic (CT) imaging. Methods Retrospectively, 117 spinal metastases were identified that received RT with follow-up CT scans >9 months following CT simulation. Contoured volumes included: the metastasis (gross tumor volume; GTV); the involved vertebra (gross bone volume; GBV); a total lytic volume (Lyt); a dominant lytic volume (Domlyt); a control volume, and the nearest uninvolved, unirradiated vertebra (control bone volume; CBV). The Hounsfield-density calibration curve was used to measure the density of these volumes before and after treatment. Results Whether using raw or control-adjusted changes, the absolute and percent change in density of the GBV, GTV, Lyt, and Domlyt volumes all significantly increased (each p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.15417