Mediators of extracellular matrix degradation and inflammation: A new team of possible biomarkers for oral squamous cell carcinoma stage

Oral cancer represents one of the most common types of cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most frequently diagnosed. Cytokines play a crucial role in inflammation, apoptosis and metastasis. Interleukin (IL)-8 promotes the direct migration of inflammatory cells. IL-6...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2021-08, Vol.22 (2), Article 877
Main Authors: Radulescu, Radu, Totan, Alexandra Ripszky, Imre, Marina Melescanu, Miricescu, daniela, Didilescu, Andreea, Greabu, Maria
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Biological markers
Biomarkers
Cell growth
Cytokines
Development and progression
Diagnosis
Enzymes
Extracellular matrix
Health aspects
Inflammation
Interleukins
Kinases
Laboratories
Medical prognosis
Metastasis
Mouth cancer
Mutation
Neutrophils
Oral cancer
Squamous cell carcinoma
Tumor necrosis factor-TNF
Tumors
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Summary:Oral cancer represents one of the most common types of cancer worldwide, with oral squamous cell carcinoma (OSCC) being the most frequently diagnosed. Cytokines play a crucial role in inflammation, apoptosis and metastasis. Interleukin (IL)-8 promotes the direct migration of inflammatory cells. IL-6 induces tumor cell proliferation, increases expression of invasiveness and angiogenetic factors or matrix metalloproteinases (MMPs), promoting metastasis. Tissue inhibitor of metalloproteinases (TIMPs) blocks the action of MMPs controlling extracellular matrix degradation and inhibiting metastasis. The aim of our study was to analyze the existence of correlations between inflammation markers (IL-6 and IL-8) and extracellular degradation protection markers such as TIMP-1 in OSCC tumors. Our study included 20 patients (12 females and 8 males) diagnosed with OSCC, recruited from January to April, 2020. IL-8, IL-6 and TIMP-1 levels were measured in the tumor cell lysates by ELISA technique, using relevant assay kits. Our results showed a positive and significant correlation between IL-6 and IL-8 (P=0.005, R=0.517) indicating that high IL-8 levels can be associated with high IL-6 levels. We also found a significant and high negative correlation (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2021.10309