The LUCA device: a multi-modal platform combining diffuse optics and ultrasound imaging for thyroid cancer screening

We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging...

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Bibliographic Details
Published in:Biomedical optics express 2021-06, Vol.12 (6), p.3392-3409
Main Authors: Cortese, Lorenzo, Lo Presti, Giuseppe, Zanoletti, Marta, Aranda, Gloria, Buttafava, Mauro, Contini, Davide, Dalla Mora, Alberto, Dehghani, Hamid, Di Sieno, Laura, de Fraguier, Sixte, Hanzu, Felicia A, Mora Porta, Mireia, Nguyen-Dinh, An, Renna, Marco, Rosinski, Bogdan, Squarcia, Mattia, Tosi, Alberto, Weigel, Udo M, Wojtkiewicz, Stanislaw, Durduran, Turgut
Format: Article
Language:English
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Summary:We present the LUCA device, a multi-modal platform combining eight-wavelength near infrared time resolved spectroscopy, sixteen-channel diffuse correlation spectroscopy and a clinical ultrasound in a single device. By simultaneously measuring the tissue hemodynamics and performing ultrasound imaging, this platform aims to tackle the low specificity and sensitivity of the current thyroid cancer diagnosis techniques, improving the screening of thyroid nodules. Here, we show a detailed description of the device, components and modules. Furthermore, we show the device tests performed through well established protocols for phantom validation, and the performance assessment for . The characterization tests demonstrate that LUCA device is capable of performing high quality measurements, with a precision in determining tissue optical and dynamic properties of better than 3%, and a reproducibility of better than 10% after ultrasound-guided probe repositioning, even with low photon count-rates, making it suitable for a wide variety of clinical applications.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.416561