Graphene‐Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation

Graphene and its derivatives have continued to garner worldwide interest due to their unique characteristics. Having expanded into biomedical applications, there have been efforts to employ their exceptional properties for the regeneration of different tissues, particularly bone. This article presen...

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Bibliographic Details
Published in:Advanced healthcare materials 2021-01, Vol.10 (1), p.e2001414-n/a
Main Authors: Daneshmandi, Leila, Barajaa, Mohammed, Tahmasbi Rad, Armin, Sydlik, Stefanie A., Laurencin, Cato T.
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials
Biodegradability
Biodegradation
biomaterials
Biomedical materials
Bone biomaterials
Bone Regeneration
bones
Chemical compounds
Graphene
Graphite
Nanomaterials
Nanostructures
Nanotechnology
Pharmacology
Regeneration
Surgical implants
Tissue Engineering
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Summary:Graphene and its derivatives have continued to garner worldwide interest due to their unique characteristics. Having expanded into biomedical applications, there have been efforts to employ their exceptional properties for the regeneration of different tissues, particularly bone. This article presents a comprehensive review on the usage of graphene‐based materials for bone regenerative engineering. The graphene family of materials (GFMs) are used either alone or in combination with other biomaterials in the form of fillers in composites, coatings for both scaffolds and implants, or vehicles for the delivery of various signaling and therapeutic agents. The applications of the GFMs in each of these diverse areas are discussed and emphasis is placed on the characteristics of the GFMs that have implications in this regard. In tandem and of importance, this article evaluates the safety and biocompatibility of the GFMs and carefully elucidates how various factors influence the biocompatibility and biodegradability of this new class of nanomaterials. In conclusion, the challenges and opportunities regarding the use of the GFMs in regenerative engineering applications are discussed, and future perspectives for the developments in this field are proposed. Graphene and its derivatives have emerged as a promising class of nanomaterials for regenerative engineering bone tissue. This review provides a comprehensive overview of the developments and advancements made in bone regenerative engineering using graphene‐based materials, and also discusses the considerations regarding their safety, biocompatibility, and biodegradability.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202001414