Association of Parental Consanguinity With Papillary Thyroid Carcinoma: A Case-Control Study

ContextPapillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many gen...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2021-07, Vol.106 (7), p.e2769-e2774
Main Authors: Zayed, Ayman A, Amarin, Justin Z, Al-Ani, Abdallah T, Altell, Tareq L, Abdelhamid, Sultan S, Qirem, Murad M, Fahmawi, Suhib M, Elshebli, Sanad M, Hamo, Khair M, Zaghlol, Louay Y, Tierney, Michael E, Zayed, Jana A, Haghighi, Alireza
Format: Article
Language:English
Subjects:
Adult
Body mass index
Cancer
Carcinoma
Carcinoma, Papillary - genetics
Case-Control Studies
Chromosome aberrations
Clinical s
Consanguinity
Disease susceptibility
Endocrinology
Female
Genetic aspects
Genetic counseling
Genetic disorders
Genetic Predisposition to Disease - genetics
Humans
Inheritance Patterns - genetics
Logistic Models
Male
Medical genetics
Middle Aged
Mutation
Oncology, Experimental
Papillary thyroid carcinoma
Pedigree
Population genetics
Risk assessment
Risk Factors
Thyroid cancer
Thyroid Neoplasms - genetics
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Summary:ContextPapillary thyroid carcinoma (PTC) is the most common type of nonmedullary thyroid carcinoma. Uncommonly, PTC is associated with multiple genetic alterations and chromosomal abnormalities and displays familial patterns of inheritance. Parental consanguinity increases susceptibility to many genetic disorders. ObjectiveThis work aimed to investigate the association of parental consanguinity with PTC. MethodsThis case-control study of PTC patients compared with healthy controls took place in a tertiary referral hospital. We recruited 200 PTC patients who were managed at the endocrinology outpatient clinics of the Jordan University Hospital, and we recruited 515 healthy controls from a nonclinical setting. We interviewed all participants and collected sociodemographic data. We reviewed the family pedigrees of each participant four generations back and excluded any participant who was related. We established whether the parents of each participant were first cousins, first cousins once removed, second cousins, or unrelated. We then used binary logistic regression to assess the association of parental consanguinity with PTC adjusted for age, sex, smoking status, body mass index, and parental education. ResultsWe recruited 715 participants. The numbers of PTC patients and healthy controls were 200 (28.0%) and 515 (72.0%), respectively. The rate of parental consanguinity was 25.5% in PTC patients and 12.2% in healthy controls. Parental consanguinity was significantly associated with PTC (adjusted odds ratio, 2.60; 95% CI, 1.63-4.17; P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgab071